I use multiple Ad Blockers which run in tandem with Ghostery. Ghostery does its job to a certain degree, buts needs help.

Along with Ghostery I use:
I don't Care About Cookies (Blocks those Pop-Ups asking you to click on accept)
Avast Online & Security
Ad Block-The Best Ad Blocker -That is the actual name – This one blocks 100% of all YouTube ADs. Even the ones that interrupt the videos
Ad Blocker Pro
Ad Block Plus – Free Ad Blocker – This extension also Blocks YouTube Ads & fights Malware
Ad Blocker Ultimate
Ad Guard Ad Blocker
AVG Online Security
Duck Duck Go Privacy Essentials
Pop-Up Blocker Strict
uBlock Origin

Having all of these extensions running in tandem, provides me a well protected browsing experience.