The only usefull way to use it with a mouse with scroller. I have a laptop and the mousepad is useless: it doesn't recognice the scroll, nor the zooming function, and zooming keys from dedicated keyboard are useless too. I haven't used it with two-scroll-mouse, but I gues the second will be useless too.
It have some "interesting" interaction in sites with embeded images like overleaf and scribd.