I use multiple machines, real and virtual. I have ghostery installed on every one. It's biggest feature is that it automates the opt out process. You just wait a couple of seconds and it's done. (Alas, this doesn't work on every website so some opt outs still require intervention.)

I do have a problem with some websites that use popups in normal operation. When this happens, I generally just try using a different browser without extensions installed. I should but haven't spent enough time to find out whether easier alternatives (like disabling Ghostery for the site) are always effective or whether some other extension or browser feature is actually causing the problem.