The only problem I'm aware of with Twitch is clips not working because of this issue: https://github.com/vatara/firefox-audio-compressor/issues/2 where videos from a different host get muted by the browser. That's out of my control.

Other than that, it works fine on Twitch. You might have another plugin, like FFZ, that is also trying to compress the audio and it's conflicting, not sure what else it could be.

If you have more details you could post in this thread https://github.com/vatara/firefox-audio-compressor/issues/20 and I could try to replicate it.