Had the same issue as the guy below. Worked great for a while, no ads, ad vault got filled up fast.

Then all of a sudden today the setup screen opened again and all my stuff was unchecked, the ad vault was empty and I had two AdNauseam icons when opening Youtube, with one of them not working at all. Removed and reinstalled and that seems to have fixed it.

Had issue on Firefox 55.03 64-bit portable, Windows 10. Also have Disconnect and Youtube Plus installed.