First of all thank You for taking the time to write a review!
That problem seems very weird to me, as I cannot replicate this by simply installing Enhancer for YouTube. Also, the behaviour you are describing seems to be the panel failing to communicate with the local storage api provided by the browser. As my extension currently relies on that to save its state across sessions, you need to have it enabled for the extension to work. If you don't know how to test this, press [F12] to open the developer tools, go to the tab Console send me the output of these commands:

!window.localStorage

and

localStorage.setItem(test, 'test'); localStorage.removeItem('test');

This should determine if local storage works as it should.