The Red Block extension provides several tools for blocking or muting groups of accounts–up to 100,000 at a time-on Twitter. You can target groups of accounts following or followed by a certain Twitter account, or all of the accounts that have retweeted or liked a particular tweet. The extension does not block every account in a group reliably on the first run–as explained by the developer, this is due to the Twitter API the extension must use to block/mute large amounts of accounts at once. However, you can save accounts within the extension to run another session of blocking or muting later. You can also un-block or un-mute groups of accounts defined in the same way as above, and without the reliability issues of blocking/muting accounts. I have found it to be a perfect replacement for Twitter Blockchain.